TransCode Therapeutics (NASDAQ: RNAZ) announced the publication of a manuscript in Molecular Imaging and Biology detailing a novel tumor-selective immunotherapy strategy that activates RIG-I signaling within cancer cells while enabling non-invasive imaging of drug delivery. The study, conducted in collaboration with Michigan State University researcher Dr. Anna Moore, describes a template-directed RIG-I agonist approach leveraging overexpressed oncogenic microRNAs such as miRNA-21 to drive intracellular immune activation and reduce off-target toxicity, and highlights the potential clinical relevance of combining tumor-specific RNA templating with the company’s TTX nanoparticle delivery platform, which is currently under clinical evaluation.
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About TransCode Therapeutics
TransCode Therapeutics is a clinical stage company pioneering immuno-oncology and RNA therapeutic treatments for high risk and advanced cancers. The company’s lead therapeutic candidate, TTX-MC138, is focused on treating metastatic tumors that overexpress microRNA-10b, a unique, well-documented biomarker of metastasis. In addition, TransCode’s portfolio includes other first-in-class therapeutic candidates designed to mobilize the immune system to recognize and destroy cancer cells. For more information, visit www.transcodetherapeutics.com.
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