- Brain cancer drug developer CNS Pharmaceuticals is finalizing preparations to begin March enrollment of patients in its potentially pivotal Phase 2 trial evaluating its promising lead candidate, Berubicin, for the overall survival improvement of glioblastoma (“GBM”) patients
- Glioblastomas are a type of brain cancer that have continued to elude effective therapy over the past century of investigation, leaving patients with expectations of approximately 15 months of survivability beyond diagnosis and recurrence after surgical removal
- A GBM patient in a small Phase 1 Berubicin safety trial 15 years ago has remained cancer-free and stable as of last November, a hint of Berubicin’s potential
- CNS Pharmaceuticals’ sublicensee partner, WPD Pharmaceuticals, is similarly preparing to launch a parallel Phase 2 adult GBM trial in Poland this year, and plans to begin a Phase 1 trial for malignant gliomas in pediatric patients by the end of the year
Glioblastoma may not be a household word but during 2020 more than 13,000 new diagnoses of the deadly brain cancer were expected to hit home for Americans, according to the National Brain Tumor Society. The service and research-funding organization reports that glioblastoma, or GBM, was first identified in scientific literature a century ago but that only four drugs and one device to treat GBM have been approved by the U.S. Food and Drug Administration (“FDA”) since then, and that none of the treatments have been able to significantly extend patients’ lives beyond a few extra months (https://ibn.fm/t9l9g). This sad fact holds true regardless of access to the best care in the world – even President Biden’s son Beau passed away from GMB, in 2015.
Texas-based biopharmaceutical company…
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