- Odyssey is a medical company developing PRV-002, a novel compound for the treatment of concussion
- Between 75-83% of all the cases of traumatic brain injury (“TBI”) among U.S. service members have been classified as mild (“mTBI”), commonly termed “concussion”
- Although concussion greatly impacts the military, there are significant gaps in the understanding of the optimal diagnostic, treatment, and management criteria
- Odyssey is looking to bridge this informational gap with its clinical trial and intends to start its U.S. Phase II trials at military training sites, subject to the FDA’s approval of the results of its Phase I study
The Center for Disease Control (“CDC”) notes that more than 430,000 U.S. service members were diagnosed with a traumatic brain injury (“TBI”) between 2000 and 2020 (https://ibn.fm/6Yycd), with 75-83% of all these cases being mild (“mTBI”), according to different studies (https://ibn.fm/0MQas). These statistics make mTBI, also known as concussion, the most common TBI affecting military personnel. But despite its prevalence, mTBI is the least understood and most difficult to diagnose of the different forms of TBI and has been a largely unexplored area of medical intervention until very recently.
In military settings, head injuries caused by shock waves from explosives, violent impact, or ballistic penetration are cited as the main causes of TBI, with most concussions resulting from blunt trauma. While symptoms from a concussion are “usually self-limited and resolve spontaneously over a period of a few…
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