A new study done by scientists in Brazil has found that cannabidiol (CBD) can reduce the aggressiveness induced by isolation. The findings of this research were published in Progress in Neuro-Pharmacology and Biological Psychiatry. The scientists were from the medical school of the University of Sao Paolo and the Sao Paolo Center of Applied Research in Neuroscience.
A resident-intruder test model was used to study what effects varying doses of CBD would have on several groups of mice isolated for several days before new ones are introduced into their cages. The prolonged isolation causes the “residents” to act aggressively towards the “intruders.”
The mice were divided into five groups, with each group having six to eight male animals. One group was given an injection of 5mg/kg of CBD. The mice in this group launched their attacks against the intruders approximately four minutes after the intruders were brought to their cage. Approximately 12 attacks were recorded for this group.
In the second group, the mice got an injection of 15mg/kg. The attacks in this group started almost 11 minutes after intruders were introduced into the cages of the resident mice. In all, five attacks were recorded, which was a marked drop from what was observed in the first group.
A third group of mice got 30mg/kg injections while a fourth group got 60mg/kg CBD injections. There was a marked change in the trend of the results because the higher doses of CBD given to the mice in these two groups didn’t produce a further reduction in their aggressiveness. Instead, the mice attacked the intruders sooner, and the number of attacks also increased.
The fifth group was the control group and didn’t get any CBD. In this group, the residents attacked the intruders barely two minutes after the intruders entered the cage, and in total, 25 attacks were recorded.
The research clearly demonstrated that in limited doses, CBD can inhibit the aggressive tendencies of the resident mice towards the intruders. However, as the dose increases, the beneficial effects are progressively lost until when high enough doses of CBD are given there is no difference between the mice which haven’t got any CBD and those which have received injections of high doses of the compound.
The study authors concluded that CBD can provide an important option in dealing with some of the psychosis-like effects of THC because CBD activates the receptors of serotonin (responsible for inducing relaxation) in the brain. They therefore called for more research to be done about the specific mechanisms through which CBD acts on the brain, and the particular dosage that can deliver benefits before the threshold is reached and the gains are reversed.
It would be enlightening to hear how the findings of this Brazil study compare with what CBD industry actors like Organigram Holdings Inc. (TSX.V: OGI) (NASDAQ: OGI) and Plus Products (CSE: PLUS) (OTCQB: PLPRF) know about the effects of CBD on aggressiveness.
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