A case report proposes that adding cannabis oil to conventional anti-seizure medications may be an effectual way to manage life-threatening seizures caused by status epilepticus that may need urgent medical treatment.
These findings support other reports and growing evidence that call attention to the anti-seizure effects that marijuana-based compounds possess. The study researchers note that despite their findings, additional research is still required to confirm the efficacy and safety of cannabis oil for epilepticus, in addition to decreasing overall seizures in patients. The study was reported in the “Journal of Neurology Research.”
In pediatric neurodegenerative disorders, the most prevalent group is neuronal ceroid lipofuscinosis. The disorders, which are also referred to as Batten disease, are caused by mutations in about 14 different genes and are divided into different types. Among all types of Batten disease, seizures are common. Status epilepticus is defined as seizures that occur successively without any separation by consciousness or seizures that last more than five minutes.
If seizures recur after withdrawal or continue for about a day even after administering anesthesia, this is referred to as super-refractory status epilepticus. Both such statuses require urgent medical attention and are life threatening.
While anti-seizure medications work, they aren’t always effective. Growing evidence showed that cannabis oil and other marijuana-based agents may help reduce the frequency of seizures. Many studies associate these benefits with CBD (cannabidiol), which is a nonpsychoactive active component found in cannabis. CBD has been found to have immunomodulatory, anti-inflammatory, neuroprotective, antioxidant and anti-seizure properties.
The first cannabis-based medicine approved in Europe and the United States to treat childhood epilepsies was Epidiolex. The medicine is an oral form of cannabidiol that has been purified. It targets two severe epilepsies: Dravet syndrome and Lennox-Gastaut syndrome. Despite this approval, however, no marijuana-based compounds have been authorized for neuronal ceroid lipofuscinosis.
University of Nicosia Medical School researchers provided a detailed outline of the case of a 25-year-old man who had CLN6 Batten disease. The individual’s seizures began at age 10 and became treatment resistant with age, leading to the use of various anti-seizure medications in different combinations. The medications included piracetam, lacosamide, lamotrigine and levetiracetam.
The man began a trial for cannabis oil that was taken in addition to anti-seizure medication. A significant reduction in seizures was experienced two weeks into the trial with results showing that eight months after the anesthesia medication had been completely withdrawn, the individual had stopped using both zonisamide and clobazam and had experienced a significant reduction in the frequency of seizures.
It should be noted that CBD has not been approved to treat seizures and more studies are needed to not only define a recommended ratio of THC/CBD but also test the safety and effectiveness of cannabis oil.
As CBD and other cannabis compounds gain more recognition for their potential therapeutic benefits, many companies are finding ways to deliver cannabis and other medicines. For example, RYAH Group Inc. is leading the way in finding AI-powered ways to measure the doses of medicine that patients take.
NOTE TO INVESTORS: The latest news and updates relating to RYAH Group Inc. are available in the company’s newsroom at https://ibn.fm/RYAH
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