Researchers Find Traits That May Help Identify Study Subjects Who Could Benefit from Psychedelic Therapy

April 6, 2021 11:39:49

The number of studies that focus on psychedelics and the benefits they possess as therapies for various mental health conditions has increased tremendously in the last few years. Psychedelics such as LSD and psilocybin mushrooms have shown their potential as possible therapies for conditions such as depression and PTSD, and while many hope that these drugs will be approved as therapies soon, there are those who are concerned about the effects these drugs may have on patients who participate in clinical trials for their study.

New research has identified traits that have been linked to negative and positive experiences on psychedelics from prior studies. This data could help forecast how participants of clinical trials will respond to psychedelic drugs in the future.

The discoveries suggest that individuals who are apprehensive or preoccupied may likely experience challenging or negative experiences from taking psychedelics while those who are able to surrender to the unknown and are more open to new experiences are likely to have a positive experience while on these mind-altering substances. Researchers note that these forecasts could be utilized by scientists to help clinical trial patients who feel hesitant be more open to therapy, perhaps by providing lower doses to begin with.

The study’s senior author and Ohio State University assistant professor of social work Alan Davis stated that their findings signaled various things that the researchers could investigate in the future, noting that it would be reasonable to administer threshold doses that were smaller than those administered in trials as a first exposure. By doing so, individuals would experience less anxiety, and once they felt the benefits, a higher dose could be administered next time.

The review was reported in the “ACS Pharmacology & Translational Science” journal, online.

The researchers analyzed 14 clinical trials and other studies carried out in the recent years that recorded the states of mind or the personality traits of their participants, as well as their associations with negative or positive experiences on psychedelics.

Central Michigan University PhD psychology candidate Jacob Aday, who was the first author of the study, explained that for the longest time, researchers involved in the field of psychedelics had questioned how they could forecast how individuals would react to these mind-altering substances.

Prior evidence suggests that psychedelics may be efficacious in treating substance use, trauma-based, anxiety and mood disorders.

Davis noted that individuals who had experienced trauma weren’t very big on surrendering to the experience while those who had absorption, acceptance and openness traits would likely experience ego dissolution.

Aday stated that they found no differences based on sex, noting that women and men both responded similarly.

The findings of this study are a valuable addition to the R&D efforts of companies such as XPhyto Therapeutics Corp. (CSE: XPHY) (OTCQB: XPHYF) (FSE: 4XT), which is involved in identifying how various psychedelic substances, including DMT and psilocybin, can be used therapeutically.

NOTE TO INVESTORS: The latest news and updates relating to XPhyto Therapeutics Corp. (CSE: XPHY) (OTCQB: XPHYF) (FSE: 4XT) are available in the company’s newsroom at

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