Traumatic brain injury is a condition that is more common than most people care to admit. Research estimates that two million-plus people visit the ER each year with cases related to TBI. These cases occur from events such as car accidents, falls and physical attacks, and they result in minor concussion or severe traumatic brain injury. Fifty percent of the TBI injuries are connected to falls by children between the ages of 1-14 years and old folks over the age of 60. The World Health Organization lists TBI among the leading causes of death in young children.
To understand how people with TBI can benefit from using marijuana, we must first understand what traumatic brain injury means. Traumatic Brain Injury is the damage to the brain which is attributed to an external force. TBI can lead to premature death or permanent disability. TBI, like concussion, is most evident among football players and war veterans. Individuals suffering from TBI display symptoms such as dizziness, headaches, nausea, speech difficulties, difficulties controlling their motor function, sensitivity to light, seizures and amnesia.
Research shows that 30 clinical trials have failed to provide much-needed treatment for TBI. However, none of these trials included the use of cannabis which when used, activates the innate cannabinoid receptors, which help in reducing swelling in the brain and improve neurological impairment. When cannabinoid 2-AG is administered into a damaged mice’s brain, its cognitive and motor function are seen to improve significantly. Marijuana can also be used to treat other physiological conditions such as insomnia.
Studies show that Traumatic Brain Injury can result in brain edema, neural impairment, increase in microglial cell number, activation and DAI (diffuse axonal injury). The damage to the brain escalates cellular permeability thus allowing water to enter the brain which causes edema. Edema formation in humans can cause one to forget minor things such as their shopping list while impulsive behaviour and spatial learning and memory issues are observed in animals. Edema formation accounts for about fifty percent mortality rate of TBI patients. To treat edema, scientists applied the use of cannabinoid receptors (CB1 and CB2) as they help in decreasing brain edema.
However, through research CB1 receptors are less involved in the treatment effect of this drug. Thus to ensure effectiveness, scientists indicate that both receptors should be used together to increase the chances of neuroprotective actions. The study was successful because the scientists were in a lab setting, and they had the advantage of administering the dosage immediately after the accident. The research on the use of CB receptors on mice was led by Raphael Mechoulam and a top team from Hebrew University.
In the world of athletics, where the use of drugs is prohibited, it would be criminal to deny the administration of medical marijuana if a doctor determines that a single dose be administered immediately after concussion.
Experts are convinced that it is these types of findings that encourage cannabis companies like Marijuana Company of America Inc. (OTCQB: MCOAD) and MustGrow Biologics Corp. (CSE: MGRO) to keep working and making better products so that more people can benefit from what marijuana has to offer.
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