180 Life Sciences (NASDAQ: ATNF)
, a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain, today announced that “Collagen VI as a driver and disease biomarker in human fibrosis” was published in the FEBS Journal as part of its State-of-the-Art Review series. The piece was authored by Lynn Williams, Thomas Layton, Nan Yang, Marc Feldmann, and Jagdeep Nanchahal from the University of Oxford. “Fibrosis of visceral organs such as the lungs, heart, kidneys and liver remain a major cause of morbidity and mortality and is also associated with many other disorders, including cancer and metabolic disease. In this review, we focus upon the microfibrillar collagen VI, which is present in the extracellular matrix (‘ECM’) of most tissues,” the abstract reads. “However, expression is elevated in numerous fibrotic conditions, such as idiopathic pulmonary disease (‘IPF’), and chronic liver and kidney diseases. Collagen VI is composed of three subunits α1, α2 and α3, which can be replaced with alternate chains of α4, α5 or α6. The C-terminal globular domain (‘C5’) of collagen VI α3 can be proteolytically cleaved to form a biologically active fragment termed endotrophin, which has been shown to actively drive fibrosis, inflammation and insulin resistance. Tissue biopsies have long been considered the gold standard for diagnosis and monitoring of progression of fibrotic disease. The identification of neoantigens from enzymatically processed collagen chains have revolutionized the biomarker field, allowing rapid diagnosis and evaluation of prognosis of numerous fibrotic conditions, as well as providing valuable clinical trial endpoint determinants. Collagen VI chain fragments such as endotrophin (‘PRO-C6’), C6M and C6Mα3 are emerging as important biomarkers for fibrotic conditions.” According to the update, 180 Life Sciences may consider these cleavage fragments as potential therapeutic targets as it expands its fibrosis portfolio.
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About 180 Life Sciences Corp.
180 Life Sciences
is a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain by leveraging the combined expertise of luminaries in therapeutics from Oxford University, the Hebrew University and Stanford University. 180 Life Sciences is leading the research into solving one of the world’s biggest drivers of disease — inflammation. The company is driving groundbreaking studies into clinical programs, which are seeking to develop novel drugs addressing separate areas of inflammation for which there are no effective therapies. 180 Life Sciences’ primary platform is a novel program to treat fibrosis using anti-TNF (tumor necrosis factor). For more information, visit the company’s website at www.180LifeSciences.com
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