Pressure BioSciences Inc.’s (PBIO) Entry into CBD Market Aims Next-Gen Nanoemulsification Platform at Critical Water-Solubility Issues

July 30, 2019 10:50:36
  • PBIO’s proprietary Ultra Shear Technology (UST) platform achieves the long sought-after ability to create truly water-soluble CBD oil that can provide optimized bioavailability
  • CBD sales are projected to reach $89 billion by 2024 with a CAGR of 37 percent (2018-2024 forecast period)
  • Analysts predict that the biggest short-term challenge for CBD businesses will be oversaturation and stiff competition in the marketplace; companies producing the highest-quality, most bioavailable CBD products are expected to earn top customer loyalty

Finding success in the lucrative yet ultra-competitive CBD industry is a daunting challenge for businesses in the space, with oversaturation in the marketplace being a real concern. The cannabis market was valued at $14.5 billion in 2018 and is projected to reach $89.1 billion by 2024, with a compound annual growth rate of 37 percent during the forecast period, according to Mordor Intelligence ( CBD manufacturers may find tapping into this booming trend to be short-lived if their CBD offerings don’t stand up to consumers’ expectations that the products they purchase are as beneficial as advertised.

Pressure BioSciences Inc. (OTCQB: PBIO), a leader in the development and sale of high pressure-based instruments, consumables and related services for the global life sciences and other industries, has developed a novel, proprietary process that has wide potential in the cannabis sector by solving one of the most critical problems facing CBD manufacturers today: the extremely poor water solubility of CBD oil. The recent launch of PBIO’s BaroShear K45 system, based on the company’s proprietary Ultra Shear Technology (UST) platform, has been optimized for the unique purpose of creating high quality, water-soluble nanoemulsions of CBD oil in water, as a news release details (

CBD, a non-psychoactive compound believed to offer powerful health benefits, is extracted from the cannabis plant in an oil. After ingestion, because oils are not well absorbed, most of the CBD is flushed from the body, leaving little of the product to provide its beneficial properties. Because of these solubility issues, many CBD products on the market today contain an inefficient over-abundance of CBD and/or undesirable chemicals to try and improve solubility and bioavailability.

Dr. Nathan Lawrence, senior advisor to Pressure BioSciences, said that PBIO solves the water-solubility problem of CBD with its patented UST platform, which uses ultra-high pressure to create extreme shearing forces to make highly stable, homogenized nanoemulsions of materials that normally do not mix, such as CBD oil and water.

“The unique concept of the BaroShear K45 system is based on PBIO’s proprietary UST platform. It was designed for the efficient and affordable manufacture of limited quantity oil-based material into high quality, water-soluble nanoemulsions,” Dr. Lawrence stated in a news release. “The BaroShear K45 system uses a custom-designed, highly responsive ultra-high pressure generating subsystem, matched to our patented BaroIsolator device and NanoGap valve. This allows for the highest effectiveness possible at working pressures up to 45,000 psi. The BaroShear K45 system is ideally suited for processing small amounts (e.g., 50 mL – 2 L) of high value product, such as CBD oil, into water-soluble nanoemulsions with high yield.”

In a critical review report on cannabidiol (CBD), the World Health Organization’s Expert Committee on Drug Dependence noted that, while CBD is seen as a useful treatment for a number of medical conditions, there are efficacy issues because of its “poor aqueous solubility.”

“The absorption of CBD from the gastrointestinal tract is erratic, and the resulting pharmacokinetic profile is variable. Bioavailability from oral delivery was estimated to be 6 percent due to significant first-pass metabolism,” the report states (

For most oil-based products, the ability to prepare them as nanoemulsions can improve the product’s absorption, medicinal benefits, visual appearance and sensory presentation. The biggest challenge in the short-term for CBD businesses will be oversaturation and stiff competition, a Forbes article notes ( As consumers start to learn more about CBD and approach products with more discerning tastes, companies will need to start differentiating themselves from their competitors through smart branding and the delivery of excellent products.

Two short videos released by PBIO ( and, showing how its patented UST platform was able to process CBD plant oil into a water-soluble nanoemulsion, give a quick lesson in PBIO’s proprietary technology. When the UST-processed CBD oil was added to different liquids – such as a soft drink, a sports drink and a beer – the nanoemulsified CBD oil completely dissolved in each liquid. For CBD companies seeking a way to stand out from the rising hordes of competition, PBIO’s BaroShear K45 system could be a true game changer.

“We are looking forward to working with the early adopters of this exciting technology platform,” Richard T. Schumacher, president and CEO of PBIO, said in a news release. “Early adopters will be the first to use the UST platform in the CBD field, thus giving them a significant head-start over companies who choose to wait or use other methods.”

For more information, visit the company’s website at

NOTE TO INVESTORS: The latest news and updates relating to PBIO are available in the company’s newsroom at

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