- Preclinical and clinical data indicate that Oncoprex immunogene therapy may be effective alone or in combination with targeted small molecule therapies; pre-clinical data also indicate potential effectiveness in combination with immunotherapies
- Lung cancer is the second-most common cancer and the leading cause of cancer deaths worldwide
- Genprex holds an exclusive license to more than 30 issued patents and several pending applications covering its platform technologies, including patents covering the therapeutic use of the TUSC2 tumor suppressor gene
- The value of the global immunotherapy drugs market is expected to surpass $385 billion by 2025, recording a CAGR of more than 14 percent from 2018 to 2025
Clinical-stage gene therapy company Genprex Inc. (NASDAQ: GNPX) is pioneering a new approach to treating cancer with its lead drug candidate, Oncoprex immunogene therapy, an investigational therapy for non-small cell lung cancer (“NSCLC”). Oncoprex is designed to interrupt cell signaling pathways that cause replication and proliferation of cancer cells, to target and kill cancer cells via receptor pathways, and to stimulate natural immune responses against cancer. Oncoprex consists of the TUSC2 tumor suppressor gene encapsulated in a positively charged lipid nanoparticle. It is injected intravenously, specifically targeting cancer cells, which generally have a negative electrical charge. Once Oncoprex is taken up into a cancer cell, the TUSC2 gene is expressed in a protein that is capable of restoring certain defective functions arising in the cancer cell (http://nnw.fm/1w2WY).
Genprex collaborators from The University of Texas MD Anderson Cancer Center presented positive preclinical data for use of the TUSC2 gene in combination with the…
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