NetworkNewsBreaks – BriaCell Therapeutics Corp. (TSX.V: BCT) (OTCQB: BCTXF) Achieves Proof of Concept in Bria-IMT Monotherapy Study; Hosting Webcast to Further Discuss Results

September 26, 2018 14:32:07

BriaCell Therapeutics (TSX.V: BCT) (OTCQB: BCTXF), an immuno-oncology focused biotechnology company with a proprietary targeted immunotherapy technology, today announced that it has achieved proof of concept in the Phase IIa study of its lead clinical candidate, Bria-IMT™, in advanced breast cancer. The data demonstrates promising anti-tumor activity of Bria-IMT™ in heavily pre-treated advanced breast cancer patients. The company is focusing on the combination study of the candidate with pembrolizumab (Keytruda®; manufactured by Merck & Co., Inc.) or ipilimumab (Yervoy®; manufactured by Bristol-Myers Squibb Company) to boost the anti-tumor activity of Bria-IMT™. Given the conclusive findings of the first 20 patients in the Phase IIa Bria-IMT™ monotherapy study, enrollment for the study is now closed. The company has initiated a combination study of Bria-IMT™ for which enrollment is now open. “Bria-IMT™ appears to be most effective in patients who match with Bria-IMT™ at 2 HLA loci (types) further supporting BriaCell’s HLA Matching Hypothesis, and the development of Bria-OTS™ to cover 90% of the patient population. We are delighted with these positive clinical findings that confirm our HLA Matching Hypothesis in the Phase I/IIa trial in advanced breast cancer showing significant tumor shrinkage without serious side effects,” BriaCell Therapeutics president and CEO Dr. Bill Williams stated in the news release. “We believe that combination studies with immune checkpoint inhibitors should create even more potent anti-cancer immune responses, leading to our strategy of combination studies of Bria-IMT™ with Keytruda® or Yervoy®.”

BriaCell is hosting a webcast at 4:15pm ET to discuss the results. The company’s president and CEO Dr. Bill Williams will present Bria-IMT™’s proof of concept clinical data during the webcast. To join the webcast, call the toll-free line in North America at 1-855-327-6837; the Toronto line at 1-416-915-3239; the Montreal line at 1-514-375-0364; or the Vancouver line at 1-778-327-3988. To listen to a replay of the webcast, call the toll-free line in North America at 1-844-512-2921.

To view the slide presentation to follow along with the webcast, visit

To view the full press release, visit

About BriaCell

BriaCell is an immuno-oncology focused biotechnology company developing targeted and safe approaches for the management of cancer. BriaCell is currently conducting a Phase I/IIa clinical trial of Bria-IMT™, its lead candidate, in a combination study with pembrolizumab [Keytruda®; manufactured by Merck & Co., Inc.] or ipilimumab [Yervoy®; manufactured by Bristol-Myers Squibb Company]. The combination study is listed in as NCT03328026. BriaCell is developing Bria-OTS™, an off-the-shelf personalized immunotherapy, for advanced breast cancer. Bria-OTS™ immunotherapy treatments are personalized to match the patient without the need for personalized manufacturing. Bria-OTS™, which is expected to cover over 90% of the patient population, is designed to produce a potent and selective immune response against the cancer of each patient while eliminating the time, expense, and complex manufacturing logistics associated with other personalized immunotherapies. For more information, visit the company’s website at

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