BriaCell Therapeutics Corp. (TSX.V: BCT) (OTCQB: BCTXF) Wednesday announced that it achieved proof of concept in the Phase IIa study of its lead clinical candidate, Bria-IMT(Trademarked), in advanced breast cancer. The company followed the after-hours news with a live webcast discussing the results, as presented by the company’s CEO Dr. Bill Williams.
The data demonstrates promising anti-tumor activity of Bria-IMT in heavily pre-treated advanced breast cancer patients. BriaCell is now focusing on the combination study of Bria-IMT with pembrolizumab (Keytruda®, manufactured by Merck & Co., Inc.) or ipilimumab (Yervoy®, manufactured by Bristol-Myers Squibb Company) in patients with advanced breast cancer.
“Bria-IMT appears to be most effective in patients who match with Bria-IMT at 2 HLA loci (types) further supporting BriaCell’s HLA Matching Hypothesis, and the development of Bria-OTS to cover 90% of the patient population. We are delighted with these positive clinical findings that confirm our HLA Matching Hypothesis in the Phase I/IIa trial in advanced breast cancer showing significant tumor shrinkage without serious side effects,” Dr. Williams stated in the press release. “We believe that combination studies with immune checkpoint inhibitors should create even more potent anti-cancer immune responses, leading to our strategy of combination studies of Bria-IMT with Keytruda® or Yervoy®.”
To view the slide presentation, visit http://nnw.fm/2SMug
To view the press release, visit http://nnw.fm/G3FrL
BriaCell is an immuno-oncology focused biotechnology company developing targeted and safe approaches for the management of cancer. BriaCell is currently conducting a Phase I/IIa clinical trial of Bria-IMT™, its lead candidate, in a combination study with pembrolizumab [Keytruda®; manufactured by Merck & Co., Inc.] or ipilimumab [Yervoy®; manufactured by Bristol-Myers Squibb Company]. The combination study is listed in ClinicalTrials.gov as NCT03328026. BriaCell is developing Bria-OTS™, an off-the-shelf personalized immunotherapy, for advanced breast cancer. Bria-OTS™ immunotherapy treatments are personalized to match the patient without the need for personalized manufacturing. Bria-OTS™, which is expected to cover over 90% of the patient population, is designed to produce a potent and selective immune response against the cancer of each patient while eliminating the time, expense, and complex manufacturing logistics associated with other personalized immunotherapies. For more information, visit the company’s website at www.BriaCell.com
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