INmune Bio (NASDAQ: INMB), an immunology company developing treatments that harness the patient’s innate immune system to fight disease, on Monday announced the initiation of a therapeutic program to treat patients with pulmonary complications from COVID-19 infection with its dominant-negative TNF inhibitor (“DN-TNF”) platform. According to the update, the program targets patients admitted to the hospital with hypoxia who do not yet require intensive respiratory support. If successful, DN-TNF treatment should decrease the need to transfer patients to the ICU and the need for mechanical ventilation. “In response to reports highlighting the role of TNF in the cytokine storm of COVID-19 and the Lancet article, ‘Trials of anti-tumor necrosis factor therapy for COVID-19 are urgently needed’ published earlier, INmune Bio is initiating a program to treat patients with pulmonary complications from COVID-19 infection,” INmune Bio CEO and Chief Medical Officer RJ Tesi MD stated in the news release. “DN-TNF targets one of the main cytokines involved in cytokine storm without causing immunosuppression. The trial targets patients not yet in ICU or on mechanical ventilation in an attempt to keep them from needing these scarce resources.”
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About INmune Bio, Inc.
INmune Bio, Inc. is a publicly traded (NASDAQ: INMB), clinical-stage biotechnology company focused on developing treatments that target the innate immune system to fight disease. INmune Bio has two product platforms. The DN-TNF product platform utilizes dominant-negative technology to selectively neutralize soluble TNF, a key driver of innate immune dysfunction and mechanistic target of many diseases. DN-TNF is currently being developed for cancer (INB03(TM)), Alzheimer’s (XPro595), and NASH (LIVNate(TM)). The Natural Killer Cell Priming Platform includes INKmune(TM) aimed at priming the patient’s NK cells to eliminate minimal residual disease in patients with cancer. INmune Bio’s product platforms utilize a precision medicine approach for the treatment of a wide variety of hematologic malignancies, solid tumors and chronic inflammation. To learn more, please visit www.INmuneBio.com.
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